GTP-binding protein SAR1b
Details
- Name
- GTP-binding protein SAR1b
- Synonyms
-
- GTBPB
- GTP-binding protein B
- SARA2
- SARB
- Gene Name
- SAR1B
- Organism
- Humans
- Amino acid sequence
-
>lcl|BSEQ0013230|GTP-binding protein SAR1b MSFIFDWIYSGFSSVLQFLGLYKKTGKLVFLGLDNAGKTTLLHMLKDDRLGQHVPTLHPT SEELTIAGMTFTTFDLGGHVQARRVWKNYLPAINGIVFLVDCADHERLLESKEELDSLMT DETIANVPILILGNKIDRPEAISEERLREMFGLYGQTTGKGSISLKELNARPLEVFMCSV LKRQGYGEGFRWMAQYID
- Number of residues
- 198
- Molecular Weight
- 22409.695
- Theoretical pI
- Not Available
- GO Classification
-
FunctionsGTP binding/GTPase activity/metal ion bindingProcessesantigen processing and presentation of exogenous peptide antigen via MHC class II/antigen processing and presentation of peptide antigen via MHC class I/cellular protein metabolic process/COPII vesicle coating/ER to Golgi vesicle-mediated transport/intracellular protein transport/membrane organization/post-translational protein modification/protein N-linked glycosylation via asparagine/small molecule metabolic processComponentscytosol/endoplasmic reticulum membrane/ER to Golgi transport vesicle membrane/Golgi cisterna membrane
- General Function
- Metal ion binding
- Specific Function
- Involved in transport from the endoplasmic reticulum to the Golgi apparatus. Activated by the guanine nucleotide exchange factor PREB. Involved in the selection of the protein cargo and the assembly of the COPII coat complex.
- Pfam Domain Function
-
- Arf (PF00025)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
-
>lcl|BSEQ0013231|GTP-binding protein SAR1b (SAR1B) ATGTCCTTCATATTTGATTGGATTTACAGTGGTTTCAGCAGTGTGCTACAGTTTTTAGGA TTATATAAGAAAACTGGTAAACTGGTATTTCTTGGATTGGATAATGCAGGAAAAACAACA TTGCTACACATGCTAAAAGATGACAGACTTGGACAACATGTCCCAACATTACATCCCACT TCCGAAGAACTGACCATTGCTGGCATGACGTTTACAACTTTTGATCTGGGTGGACATGTT CAAGCTCGAAGAGTGTGGAAAAACTACCTTCCTGCTATCAATGGCATTGTATTTCTGGTG GATTGTGCAGACCACGAAAGGCTGTTAGAGTCAAAAGAAGAACTTGATTCACTAATGACA GATGAAACCATTGCTAATGTGCCTATACTGATTCTTGGGAATAAGATCGACAGACCTGAA GCCATCAGTGAAGAGAGGTTGCGAGAGATGTTTGGTTTATATGGTCAGACAACAGGAAAG GGGAGTATATCTCTGAAAGAACTGAATGCCCGACCCTTAGAAGTTTTCATGTGTAGTGTG CTCAAAAGACAAGGTTACGGAGAAGGCTTCCGCTGGATGGCACAGTACATTGATTAA
- Chromosome Location
- 5
- Locus
- Not Available
- External Identifiers
-
Resource Link UniProtKB ID Q9Y6B6 UniProtKB Entry Name SAR1B_HUMAN HGNC ID HGNC:10535 - General References
-
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- Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
- Jones B, Jones EL, Bonney SA, Patel HN, Mensenkamp AR, Eichenbaum-Voline S, Rudling M, Myrdal U, Annesi G, Naik S, Meadows N, Quattrone A, Islam SA, Naoumova RP, Angelin B, Infante R, Levy E, Roy CC, Freemont PS, Scott J, Shoulders CC: Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders. Nat Genet. 2003 May;34(1):29-31. [Article]
- Annesi G Aguglia U,塔伦蒂诺P,安妮i F, De Marco EV, Civitelli D, Torroni A, Quattrone A: SIL1 and SARA2 mutations in Marinesco-Sjogren and chylomicron retention diseases. Clin Genet. 2007 Mar;71(3):288-9. [Article]
- Treepongkaruna S, Chongviriyaphan N, Suthutvoravut U, Charoenpipop D, Choubtum L, Wattanasirichaigoon D: Novel missense mutations of SAR1B gene in an infant with chylomicron retention disease. J Pediatr Gastroenterol Nutr. 2009 Mar;48(3):370-3. [Article]