Reaction:交流etaminophento1 product

Reaction
交流etaminophen
DB00316
交流etaminophen sulfate
DBMET00653
Reaction type
sulfation
Direction
Major circulating metabolite?
No
Spontaneous?
No
交流tivity
unknown
References
  1. Whirl-Carrillo M, McDonagh EM, Hebert JM, Gong L, Sangkuhl K, Thorn CF, Altman RB, Klein TE: Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012 Oct;92(4):414-7. doi: 10.1038/clpt.2012.96. [Article]
  2. Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE: PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenet Genomics. 2015 Aug;25(8):416-26. doi: 10.1097/FPC.0000000000000150. [Article]
  3. 交流etaminophen FDA label [File]
Comments
30 to 44% of acetaminophen undergoes this process[A35815].
Enzymes
Enzyme Km Vmax Role
Sulfotransferase 1A1 Not Available Not Available confirmed
Sulfotransferase 1A3/1A4 Not Available Not Available confirmed
Bile salt sulfotransferase Not Available Not Available confirmed