Reaction:Anagrelideto1 product

Reaction
Anagrelide
DB00261
6,7-dichloro-3-hydroxy-1,5 dihydro-imidazo[2,1-b]quinazolin-2-one
DBMET00772
Reaction type
3-hydroxylation
Direction
Major circulating metabolite?
Yes
Spontaneous?
No
交流tivity
unknown
References
  1. Wang G, Franklin R, Hong Y, Erusalimsky JD: Comparison of the biological activities of anagrelide and its major metabolites in haematopoietic cell cultures. Br J Pharmacol. 2005 Oct;146(3):324-32. doi: 10.1038/sj.bjp.0706341. [Article]
  2. FDA Approved Drug Products: Agrylin (anagrelide) oral capsules [Link]
Comments
Not Available
Enzymes
Enzyme Km Vmax Role
Cytochrome P450 1A2 Not Available Not Available implied