Pramipexole dihydrochloride monohydrateProduct ingredient forPramipexole
- Name
- Pramipexole dihydrochloride monohydrate
- Drug Entry
-
Pramipexole
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD). It is anon-ergot dopamine agonistdrug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)6. It was first approved by the FDA in 199712. Parkinson's Disease is one of the most common neurodegenerative disorders and causes a high level of disability in patients2, leading to increased difficulty in performing activities of daily living due to symptoms that progress over time3. The prevalence of Parkinson's Disease worldwide has increased from approximately 2.5 million in 1990 to about 6.1 million in 20164. This increase may be attributed to an aging population along with other contributing factors4.
In addition to the above FDA approval for Parkinson's Disease, pramipexole was also approved by the FDA in 2006 for the treatment of Restless Legs Syndrome (RLS)8. RLS is a sleep-related disorder characterized by unpleasant sensations in the lower extremities, often accompanied by an uncontrollable urge to move the legs9.
- Accession Number
- DBSALT001198
- Structure
-
Structure for Pramipexole dihydrochloride monohydrate (DBSALT001198)
- Synonyms
- pramipexole dihydrochloride
- UNII
- 3D867NP06J
- CAS Number
- 191217-81-9
- Weight
-
Average: 302.26
Monoisotopic: 301.0782389 - Chemical Formula
- C10H21Cl2N3OS
- InChI Key
- APVQOOKHDZVJEX-QTPLPEIMSA-N
- InChI
-
InChI=1S/C10H17N3S.2ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;;/h7,12H,2-6H2,1H3,(H2,11,13);2*1H;1H2/t7-;;;/m0.../s1
- IUPAC Name
-
(6S)-2-imino-N-propyl-2,3,4,5,6,7-hexahydro-1,3-benzothiazol-6-amine hydrate dihydrochloride
- SMILES
-
O.Cl.Cl.[H][C@@]1(CCC2=C(C1)SC(=N)N2)NCCC
- External Links
-
- ChemSpider
- 145780
- ChEBI
- 51147
- ChEMBL
- CHEMBL3182733
- Wikipedia
- Pramipexole
- Predicted Properties
-
Property Value Source Water Solubility 0.746 mg/mL ALOGPS logP 1.42 ALOGPS logP 1.02 Chemaxon logS -2.4 ALOGPS pKa (Strongest Acidic) 11 Chemaxon pKa (Strongest Basic) 9.83 Chemaxon Physiological Charge 1 Chemaxon Hydrogen Acceptor Count 3 Chemaxon Hydrogen Donor Count 3 Chemaxon Polar Surface Area 47.91 Å2 Chemaxon Rotatable Bond Count 3 Chemaxon Refractivity 73.52 m3·mol-1 Chemaxon Polarizability 24.35 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like规则 No Chemaxon
