Ramosetron hydrochlorideProduct ingredient forRamosetron
- Name
- Ramosetron hydrochloride
- Drug Entry
-
Ramosetron
Ramosetron is aserotonin 5-HT3 receptor antagonistcommonly employed to treat nausea and vomiting, in addition to certain diarrheal conditions. It is believed to have higher potency and longer antiemetic action than other 1st generation 5-HT3 antagonists such as ondansetron. Currently, ramosetron is only approved for use Japan and in certain Southeast Asian countries.
- Accession Number
- DBSALT001285
- Structure
-
Structure for Ramosetron hydrochloride (DBSALT001285)
- Synonyms
- Ramosetron HCl
- UNII
- 9551LHD87E
- CAS Number
- 132907-72-3
- Weight
-
Average: 315.8
Monoisotopic: 315.1138399 - Chemical Formula
- C17H18ClN3O
- InChI Key
- XIXYTCLDXQRHJO-RFVHGSKJSA-N
- InChI
-
InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1
- IUPAC Name
-
(5R)-5-(1-methyl-1H-indole-3-carbonyl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole hydrochloride
- SMILES
-
Cl.CN1C=C(C(=O)[C@@H]2CCC3=C(C2)N=CN3)C2=C1C=CC=C2
- External Links
-
- KEGG Drug
- D02016
- ChemSpider
- 97111
- ChEBI
- 32088
- ChEMBL
- CHEMBL3181841
- Predicted Properties
-
Property Value Source Water Solubility 0.0696 mg/mL ALOGPS logP 2.22 ALOGPS logP 2.24 Chemaxon logS -3.6 ALOGPS pKa (Strongest Acidic) 12.68 Chemaxon pKa (Strongest Basic) 6.36 Chemaxon Physiological Charge 0 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 1 Chemaxon Polar Surface Area 50.68 Å2 Chemaxon Rotatable Bond Count 2 Chemaxon Refractivity 82.14 m3·mol-1 Chemaxon Polarizability 31.2 Å3 Chemaxon Number of Rings 4 Chemaxon Bioavailability 1 Chemaxon Rule of Five Yes Chemaxon Ghose Filter Yes Chemaxon Veber's Rule No Chemaxon MDDR-like Rule No Chemaxon
