Distigmine bromideProduct ingredient forDistigmine
- Name
- Distigmine bromide
- Drug Entry
-
Distigmine
Distigmine is a parasympathomimetic agent with a longer duration of action and enhanced drug accumulation compared toPyridostigmineandNeostigmine. It is an anticholinergic drug and long-acting reversible carbamate cholinesterase inhibitor that binds directly and competitively to the agonist binding sites of muscurinic receptors. Distigmine is available in several countries as a treatment of underactive detrusor and voiding dysfunction in the urinary tract where the active ingredient is distigmine bromide. It improves detrusor function thereby restoring normal voiding patterns in patients suffering from detrusor underactivity2.
- Accession Number
- DBSALT003115
- Structure
-
Structure for Distigmine bromide (DBSALT003115)
- Synonyms
- Bromure de distigmine/Bromuro de distigmina/Distigmine bromide/Distigmini bromidum
- External IDs
- 240-013-0/BC-51
- UNII
- 750F36OP6J
- CAS Number
- 15876-67-2
- Weight
-
Average: 576.33
Monoisotopic: 574.079032 - Chemical Formula
- C22H32Br2N4O4
- InChI Key
- GJHSNEVFXQVOHR-UHFFFAOYSA-L
- InChI
-
InChI=1S/C22H32N4O4.2BrH/c1-23-13-9-11-19(17-23)29-21(27)25(3)15-7-5-6-8-16-26(4)22(28)30-20-12-10-14-24(2)18-20;;/h9-14,17-18H,5-8,15-16H2,1-4H3;2*1H/q+2;;/p-2
- IUPAC Name
-
1-methyl-3-{[methyl({6-[methyl({[(1-methylpyridin-1-ium-3-yl)oxy]carbonyl})amino]hexyl})carbamoyl]oxy}pyridin-1-ium dibromide
- SMILES
-
[Br-].[Br-].CN(CCCCCCN(C)C(=O)OC1=CC=C[N+](C)=C1)C(=O)OC1=C[N+](C)=CC=C1
- External Links
-
- ChemSpider
- 25613
- ChEBI
- 31512
- ChEMBL
- CHEMBL1098285
- Wikipedia
- Distigmine
- Predicted Properties
-
Property Value Source Water Solubility 0.00067 mg/mL ALOGPS logP -2.6 ALOGPS logP -5.6 Chemaxon logS -5.9 ALOGPS Physiological Charge 2 Chemaxon Hydrogen Acceptor Count 2 Chemaxon Hydrogen Donor Count 0 Chemaxon Polar Surface Area 66.84 Å2 Chemaxon Rotatable Bond Count 11 Chemaxon Refractivity 116.06 m3·mol-1 Chemaxon Polarizability 46.02 Å3 Chemaxon Number of Rings 2 Chemaxon Bioavailability 0 Chemaxon Rule of Five No Chemaxon Ghose Filter No Chemaxon Veber's Rule No Chemaxon MDDR-like规则 No Chemaxon
